Detalhe da pesquisa
1.
Nuclear Pores Promote Lethal Prostate Cancer by Increasing POM121-Driven E2F1, MYC, and AR Nuclear Import.
Cell
; 174(5): 1200-1215.e20, 2018 08 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-30100187
2.
A Small Molecule RAS-Mimetic Disrupts RAS Association with Effector Proteins to Block Signaling.
Cell
; 165(3): 643-55, 2016 Apr 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-27104980
3.
A Contaminant Impurity, Not Rigosertib, Is a Tubulin Binding Agent.
Mol Cell
; 79(1): 180-190.e4, 2020 07 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-32619468
4.
Novel induction of CD40 expression by tumor cells with RAS/RAF/PI3K pathway inhibition augments response to checkpoint blockade.
Mol Cancer
; 20(1): 85, 2021 06 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-34092233
5.
B-myb is an essential regulator of hematopoietic stem cell and myeloid progenitor cell development.
Proc Natl Acad Sci U S A
; 111(8): 3122-7, 2014 Feb 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-24516162
6.
JNK-associated Leucine Zipper Protein Functions as a Docking Platform for Polo-like Kinase 1 and Regulation of the Associating Transcription Factor Forkhead Box Protein K1.
J Biol Chem
; 290(49): 29617-28, 2015 Dec 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-26468278
7.
Discovery of 2-(1H-indol-5-ylamino)-6-(2,4-difluorophenylsulfonyl)-8-methylpyrido[2,3-d]pyrimidin-7(8H)-one (7ao) as a potent selective inhibitor of Polo like kinase 2 (PLK2).
Bioorg Med Chem
; 24(4): 521-44, 2016 Feb 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-26762835
8.
Myb permits multilineage airway epithelial cell differentiation.
Stem Cells
; 32(12): 3245-56, 2014 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-25103188
9.
A role for the epidermal growth factor receptor signaling in development of intestinal serrated polyps in mice and humans.
Gastroenterology
; 143(3): 730-740, 2012 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-22643351
10.
Hydrothiolation of benzyl mercaptan to arylacetylene: application to the synthesis of (E) and (Z)-isomers of ON 01910·Na (Rigosertib®), a phase III clinical stage anti-cancer agent.
Org Biomol Chem
; 11(12): 1964-77, 2013 Mar 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-23386308
11.
ON01910, a non-ATP-competitive small molecule inhibitor of Plk1, is a potent anticancer agent.
Cancer Cell
; 7(3): 275-86, 2005 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-15766665
12.
Master Transcription Factor Reprogramming Unleashes Selective Translation Promoting Castration Resistance and Immune Evasion in Lethal Prostate Cancer.
Cancer Discov
; 13(12): 2584-2609, 2023 12 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-37676710
13.
Transforming growth factor-ß adaptor, ß2-spectrin, modulates cyclin dependent kinase 4 to reduce development of hepatocellular cancer.
Hepatology
; 53(5): 1676-84, 2011 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-21520178
14.
Screening candidate anticancer drugs for brain tumor chemotherapy: pharmacokinetic-driven approach for a series of (E)-N-(substituted aryl)-3-(substituted phenyl)propenamide analogues.
Invest New Drugs
; 30(6): 2263-73, 2012 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-22383114
15.
Preclinical pharmacokinetic and pharmacodynamic evaluation of novel anticancer agents, ON01910.Na (Rigosertib, Estybon™) and ON013105, for brain tumor chemotherapy.
Pharm Res
; 29(9): 2499-511, 2012 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-22678771
16.
Conditional c-myb knockout in adult hematopoietic stem cells leads to loss of self-renewal due to impaired proliferation and accelerated differentiation.
Proc Natl Acad Sci U S A
; 106(51): 21689-94, 2009 Dec 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-19955420
17.
CDK4: a master regulator of the cell cycle and its role in cancer.
Genes Cancer
; 13: 21-45, 2022.
Artigo
em Inglês
| MEDLINE | ID: mdl-36051751
18.
TGFß reprograms TNF stimulation of macrophages towards a non-canonical pathway driving inflammatory osteoclastogenesis.
Nat Commun
; 13(1): 3920, 2022 07 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-35798734
19.
Regulation of neurite outgrowth by interactions between the scaffolding protein, JNK-associated leucine zipper protein, and neuronal growth-associated protein superior cervical ganglia clone 10.
J Biol Chem
; 285(6): 3548-3553, 2010 Feb 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-19959466
20.
Epigenetic silencing of beta-spectrin, a TGF-beta signaling/scaffolding protein in a human cancer stem cell disorder: Beckwith-Wiedemann syndrome.
J Biol Chem
; 285(46): 36112-20, 2010 Nov 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-20739274